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Description
Peroxidases, including glutathione peroxidase 4 (GPX4), metabolize hydroperoxy-phospholipids to hydroxy derivatives to prevent ferroptotic death, but consume reduced glutathione (GSH)
2023;11(2):p
Antioxidants are critical in neutralizing these harmful molecules, thus supporting cellular function
Wittgen et al., 2012) (Meyer zu Schwabedissen and Kroemer, 2011)
However, sustained overactivation can upregulate enzymes involved in lipid synthesis, increasing the accumulation of polyunsaturated fatty acids (PUFAs) and providing molecular targets for ferroptosis (87)
