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Though amelanotic melanomas are uncommon, representing less than 2% of all melanoma cases, they constitute 40% up to 75% of melanomas found in the oral cavity [32]

The disorder is caused by a somatic mutation of the guanine nucleotide-binding protein, -stimulating ( GNAS ) complex locus gene, leading to constitutive activation of the subunit of the stimulatory G protein (Gs)[99]

We next used transmission electron microscopy (TEM) to examine intestinal cell cytoplasm in L4, D2, and D3 hermaphrodites (S1 Fig)

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