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Myricetin therapy in SKH-1 hairless mice effectively reduced UV-induced neovascularization by inhibiting HIF-1 expression and PI-3 kinase activity, which is a critical target for VEGF and MMP suppression [99]

PMID 12835357

Studies have demonstrated that in pancreatic cancer, targeting Gln metabolism in conjunction with ERK signaling pathway inhibitors can halt pancreatic cancer cell metabolism and treatment resistance, thereby enhancing treatment outcomes (24)