modifications to glutathione General scheme of metabolism (According Foyer and Noctor Glutathione! - PMC
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Cisplatin exerts anticancer effects via multiple mechanisms, yet its most prominent (and best understood) mode of action involves the generation of DNA lesions followed by the activation of the DNA damage response and the induction of mitochondrial apoptosis
Depending on the distribution of CB1Rs between glutamatergic and GABAergic inputs, eCBs can decrease or exacerbate epileptic seizures, respectively, by affecting the hippocampal E/I balance, a condition of critical relevance for shaping the functional connectivity of the hippocampus in epileptogenesis [24]
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doi: 10.1126/science.1209985 38 Martnez-VargasDValds-CruzAMagdaleno-MadrigalVMFernndez-MasRAlmazn-AlvaradoS
