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Omega-3 PUFA deficit causes structural and functional abnormalities in brain Depletion of omega-3 PUFAs in patients with schizophrenia could be due to a long consumption of unbalanced high omega-6 diet during early developmental stages, and throughout the illness, abnormal uptake and transport of omega-3 fatty acids within neuronal cells, and increased release and oxidation of omega-3 fatty acids from the neuronal cell membrane phospholipids due to an elevated PLA2 activity

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