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doi: 10.1007/BF00965509

Intermolecular hydrogen bonds with water can create a hydration shell that weakens membrane partitioning by increasing peptide polarity and reducing the octanolwater partition coefficient [81]

10.1021/ac3007939 53

Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to estimate their frequency or establish a causal relationship to drug exposure: Blood and lymphatic system disorders:hemolytic anemia, leukocytosis Cardiac disorders:cardiospasm, congestive heart failure, conduction block, orthostatic hypotension and syncope, palpitations, bradycardia, atrial fibrillation, myocardial infarction, cardiac arrest, arrhythmia, ventricular ectopic activity, including ventricular tachycardia and QT prolongation

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