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There are several types of omega-3 fats, but the most important ones can be categorized into two main groups: Essential omega-3 fatty acids: Alpha-linolenic acid (ALA) is the only essential omega-3 fatty acid

Concretely, lactylation of PDHA1 at K336 and CPT2 at K457/8 results in the inactivation of both enzymes and the inhibition of OXPHOS by restricting acetyl-CoA influx from pyruvate and fatty acid oxidation, respectively

Neuropharmacology 104 , 417 (2016)

Therefore, SHANK3 mutations lead to various symptoms, including behavioral symptoms of ASD

Carnitine transmembrane transport Carnitine transport in and out of cells depends on specific transporters, among which OCTN2 transporter plays a key role