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While there is no evidence of common structural or functional brain alterations in PAIS, probably due to its heterogeneous origin and lack of conceptualization, ME/CFS has been extensively studied with MRI (magnetic resonance imaging), as recently reviewed by Nelson et al

O., Geiss, H

Mission Viejo, California, USA

Subsequent investigations demonstrated similar increases in creatine and phosphocreatine after 30 days of low-dose creatine administration (3 g/day) and after a loading dose (20 g/day for 6 days) and 2 g/day for 1 month [52,53,54]
Impact of air pollution and weather on dry eye
