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Beyond-use dating (BUD) determines how long the compound remains clinically effective

DIAGNOSTIC TESTING Although patients with either large or small fiber neuropathy may have subjective hyperesthesia or numbness of the distal lower extremities, the absence of significant abnormalities on neurologic examination should prompt consideration of small fiber neuropathy

Documented pre-existing humoral and cellular immunity to AAV capsids and frequently utilized Cas orthologs (SpCas9, SaCas9) can neutralize vectors or induce T-cell-mediated clearance of edited cells

Nakaki, T., Mita, S., Yamamoto, S., Nakadate, T

Collectively, our observations show that mitochondrial functions are compromised in hlh-30 animals and that hlh-30 animals rewire their metabolism to largely depend on functional peroxisomes during starvation, underlining the importance of metabolic plasticity to maintain survival