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The total amount of glutathione molecules (GSH + 2GSSG) is shown in Fig

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26 The compound has been available in clinical practice for several decades to treat various medical conditions, including bronchitis, acute respiratory distress syndrome, paracetamol intoxication, chemotherapy-related toxicity, doxorubicin cardiotoxicity, heavy metal intoxication, ischemia-reperfusion cardiac injury, human immunodeficiency virus infection or acquired immunodeficiency syndrome, and neuropsychiatric disorders

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We therefore wondered whether lack of Thr or Cys would also trigger similar generic AA starvation responses, even though the final fate of deprivation of either AA was a distinct form of cell death