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Its research scope has expanded from cardiovascular diseases to other systemic diseases, including pulmonary, kidney, neurological, and pancreatic diseases

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Consistently, in a cohort of 75,725 participants, the cumulative incidences of ischemic vascular disease and ischemic heart disease were reduced in heterozygotes for loss-of-function mutations in APOC3 (R19X or A43T or IVS2 + 1G A) as compared with noncarriers, with corresponding risk reductions of 41% and 36% [4]