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The overall effect is the formation of thrombi within small and large blood vessels
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The activity of MMPs generates soluble and small extracellular-matrix fragments (e.g., biglycan, decorin, versican, fragments of fibronectin, hyaluronan), which can act as DAMPs
[8] The peptide also closed pathological fistulas between organs in preclinical models: colocutaneous, gastrocutaneous, and esophagocutaneous connections
