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The supplementation of several antioxidants to 250 mg of silymarin demonstrated histological improvements as well as ameliorated ALT content [284]

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Dietary vitamins and selenium diminish the development of mechanically induced osteoarthritis and increase the expression of antioxidative enzymes in the knee joint of STR/1N mice

The other type of MDR is based on overexpression of GSTs, which can result in direct detoxification of chemotherapeutics and/or inhibition of the MAPK signaling pathway [12]