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It can cross the BBB as well (Canistro et al., 2010)

Nuclear IGF-IR regulates gene expression While IGF-IR is usually localized at the plasma membrane in normal cells, it often translocates into the cytoplasm and nucleus in cancer cells even though it does not have the nuclear localization signal [78,79,80]
The effects of a single treatment can last several days in your system, which is why treatments are usually spaced out rather than done daily

Immunol Invest 51(3):602618 Kim Y, Chongviriyaphan N, Liu C, Russell RM, Wang X-D (2012) Combined -tocopherol and ascorbic acid protects against smoke-induced lung squamous metaplasia in ferrets

[101] demonstrated that the insulin/mTOR/STAT3 pathway acted through the transcription of the Ikaros gene to induce the commitment of hemotopoietic progenitors to the lymphoid lineage
