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Liver injury caused by acetaminophen is initiated by cytochrome P450 (CYP)-mediated bioactivation to N -acety- para -benzoquinoneimine (NAPQI), which is a chemically reactive intermediate that is formed at high levels following overdosage and triggers a complex cascade of events, which ultimately result in hepatocellular necrosis (Hinson et al
Tadayyon, A., Nikneshan, P
[PubMed] [Google Scholar] 108.Nishida N., Yano H., Nishida T., Kamura T., Kojiro M
Stearoyl-CoA desaturase 1 protects ovarian cancer cells from ferroptotic cell death
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