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doi: 10.1097/SLA.0000000000001691 65 XuYTangYLuJZhangWZhuYZhangSet al

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Imaging studies in both animals and humans reveal that decreased D 2 receptor availability is a striking common feature of chronic exposure to drugs of abuse including cocaine, alcohol, methamphetamine, heroin, nicotine, and cannabis (for review see Volkow et al., 2009)
Sky is not the limit, 200mg is

This increased burden can lead to a compensatory state, ultimately reducing renal filtration function and causing pathological changes
