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At the same time, the absence of Gsr and TrxR in these cells results in an oxidized cytosol in which Grx1-disulfide or Grx-SSG accumulates
Zieliska M, uszczki E, Dere K
Cell 175 , 372386.e17 (2018)
Microbiota-related changes in bile acid & tryptophan metabolism are associated with gastrointestinal dysfunction in a mouse model of autism
It should be noted, however, that ALDH1A1, but not CYP2E1, is a downstream target of NRF2, which was found to be activated in untreated GCLM KO mouse liver
