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ChaC1 is upregulated under stress conditions such as ER stress and amino acid starvation [105], whereas ChaC2 is constitutively expressed and may act in a housekeeping fashion [5]
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However, severe symptoms can be observed in the cases of higher doses

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In their clinical testing, 100% of participants saw an instant hydration boost, and 97% reported improved firmness within a week

Li H, Liu L