ipamorelin sermorelin or tesamorelin vs. vs. Tesamorelin vs Sermorelin, Ipamorelin, and

Introduction: Introduction: AOD-9604 is a synthetic peptide fragment of human growth hormone (hGH 177191) engineered to replicate hGHs fat-metabolism effects without altering IGF-1 or glucose levels. In preclinical research, it promoted lipolysis (fat breakdown) and reduced lipogenesis (fat storage) through receptor-independent mechanisms. AOD-9604 Fast Facts Class: Synthetic hGH fragment analog (Tyr-hGH 177191) Intended purpose: Stimulate fat metabolism while avoiding hGHs growth or glucose effects Mechanism: Increases fat oxidation, enhances lipolysis, suppresses lipogenesis Distinct from hGH: Does not activate the growth hormone receptor or raise IGF-1 Development stage: Completed Phase II trials

J., Romero B

10.13389/j.cnki.rao.2023.0155 146 ZhangB.RuscianoD.OsborneN

doi: 10.1080/09603123.2020.1805415 29 DasS.GreenA

[DOI] [PMC free article] [PubMed] [Google Scholar] 6.Dai L, Golembiewska E, Lindholm B, Stenvinkel P