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First, we found that exposure to IGF-1 for 48h increased [ 3 H]-thymidine incorporation at all concentrations tested (0.1100 ng/mL

doi: 10.1074/jbc.M114.625053

however, this ratio was reduced in hyh samples (Supplementary Fig
Strikingly, 0.1mM Epitalon significantly reduced the fragmentation rate, from 13% in the aged group to 5.8% in the Epitalon supplement group (Figure 2B)
