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doi: 10.1007/s00204-023-03476-6 29 TangXLiuJYaoSZhengJGongXXiaoB

57 Positive effects of B12 on homocysteine levels have also been observed in other patient populations, including healthy adults, 46 vegetarian women, 58 generally healthy women, 59 older adults with elevated MMA and homocysteine, 37 and patients with type 2 diabetes mellitus

Ferroptosis is an iron-dependent regulated necrosis that is considered a byproduct of cellular metabolism because of its close association with oxygen, iron, and lipid metabolism (116), it is dependent on the metabolites reactive oxygen species (ROS), phospholipids containing polyunsaturated fatty acid chains (PUFA-PL), and the transition metal iron, and exhibits biochemical features of iron accumulation and unrestricted lipid peroxidation, as well as morphologic alterations such as loss of plasma membrane integrity, mitochondrial abnormalities, cytoplasmic swelling, and moderate chromatin condensation (117, 118)

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GHK-Cu timing matters less for systemic effects, though evening administration may support overnight regenerative processes