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This improvement was hypothesized to be attributed to its purported anti-inflammatory action, including a potential decrease in myeloperoxidase (MPO) activity and histological inflammatory cell influx

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A phase 2b clinical trial was completed in Australia on 300 obese individuals

NNMT inhibitors reduced intracellular 1-MNA, increased intracellular NAD + and S-(5-adenosyl)-L-methionine (SAM), and suppressed lipogenesis in adipocytes