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In terms of iron metabolism and homeostasis in immune cells, a study revealed that iron overload promotes abnormal differentiation of pathogenic T cells, including follicular helper T cells, by regulating DNA demethylation, thus exacerbating autoantibody production and the development of systemic lupus erythematosus (SLE) [26]

Zhao R et al

Safety facets and issues related to nanotechnological approaches As there is a remarkable use of nano-tailored drug delivery, the main concern is their safety

In 2024, three different groups published several examples of 5-aminothalidomide-based PROTACs targeting Fms-like protein tyrosine receptor kinase 3 (FLT3), an established target in acute myeloid leukemia (AML) 103

These transcription factors are involved in the synthesis of several antioxidant enzymes (e.g., glutathione reductase, glutathione peroxidases, glutaredoxin, and glutathione- S -transferase), many of which are closely related to the cellular antioxidant, glutathione (Espinosa-Diez et al