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Clinical case reports (2023) document treatment failure and refractory hypotension when these drugs are infused together

Individuals with lower socioeconomic status, for example, may lack access to effective oral healthcare or be less likely to adopt preventive dental practices due to the constraints of their habitus, which is shaped by factors such as income, education, and cultural values (78, 79)

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Among these, non-covalent DPP1 inhibitors have attracted considerable attention due to their unique pharmacokinetic characteristics and potential safety advantages ( 10 Comparison of DPP1 inhibitors with other treatment strategies 10.1 Comparison with direct NSP inhibitors Direct NSP inhibitors, particularly NE inhibitors such as AZD9668, have undergone Phase II studies in bronchiectasis patients but failed to significantly improve patient clinical symptoms (Stockley et al., 2013)

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