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For instance, we observed significant disturbances in glutathione and glutathione-related enzyme levels in elderly patients treated for hypertension (9)

of 2a as a fluorescent labeling reagent in the presence of 1.0 equiv

NRF2 is the master switch of the cellular antioxidant response: when oxidative stress is sensed, KEAP1 (the NRF2 repressor) is oxidized at critical cysteine residues, releasing NRF2 for nuclear translocation and ARE-driven upregulation of the complete antioxidant gene set including GCLC, GCLM, GSR, GPX1, GSTP1, and the thioredoxin system

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