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doi: 10.1007/s00441-018-2922-y

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In skin, the SIRTs are linked to the preservation of collagen in the dermis and their activation is important in wound healing and regeneration of skin by promoting keratinocyte proliferation
The cycling protocols commonly recommended are partly based on this theoretical concern, though actual tolerance development has not been documented

Important Medical Disclaimer: BPC-157 is not FDA-approved for human use
