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In the presence of excess reactive oxygen species (ROS), PFKFB3 is inactivated, leading to a shift in glucose utilization from glycolysis to the PPP (9)

CHAC1 emerges as a key stress-responsive effector, transcriptionally upregulated via the ATF4-CHOP axis during endoplasmic reticulum stress and amino acid deprivation

10.1016/j.clnesp.2022.03.031 242

If cloudiness persists after 15 minutes of gentle intermittent mixing, the vial is likely compromised

We further aim to conceptualize the molecular mechanisms at the centre of these associations and identify actionable gut microbiome-based targets, while contextualizing the current knowledge within the clinical scenario and emphasizing the limitations of the field that need to be overcome