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This is a mechanistic inference, not a human finding, but it illustrates why unregulated IGF-1R agonism is not treated casually in the scientific literature
P294, P295, P803, P968, P969, P970, P1178 Aseeva E

Emodin alleviates joint inflammation and bone erosion in rats with collagen-induced arthritis by inhibiting ferroptosis and degrading matrix metalloproteinases
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They brighten skin, reduce pigmentation, boost immunity, detox the liver, and improve energy