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Muscle weight ratios were 0.980.13 for group A, 0.700.10 for group B, and 0.540.05 for group C

3 Advances in emerging drug therapies: genetically targeted therapies TDP-43 is an RNA-binding protein, and cytoplasmic TDP-43 aggregates are present in sporadic and familial ALS, in addition to familial ALS caused by mutations in SOD1 , and its aberrant aggregation and aberrant function have been implicated in the pathogenesis of ALS (31, 32)

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