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1A), but not in the control group (n = 32) (0.040 0.048 vs

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A cardiac-centred approach to HFpEF diagnosis using NPs is a good starting point, and is actually promoted by the Heart Failure Association through the Peptide for Life initiative.165 However, a holistic approach including biomarkers that provide information on non-cardiac components of the HFpEF syndrome may enrich our understanding of the disease and may be useful in classifying HFpEF phenotypes/endotypes that may guide patient selection in HFpEF trials ( Figure 1 ).166 Because of the risk of bias in current HFpEF biomarker studies, methodologically well-designed studies with a uniform reference diagnosis are urgently needed to determine the incremental value of circulating biomarkers for the diagnosis of HFpEF.167

Mensah, GA

If the next dose is due, skip the missed one, do not double the dosage but instead return to your regular dosing schedule and continue from there