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This selectivity of the blood vessels acts as a barrier- called the blood-brain barrier

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The beneficial microflora can also produce many metabolic products that moderate the interaction between the epithelium and the immune system and generate antimicrobial substances, inhibiting pathogens [14]

Cutting Edge: Enhanced Clonal Burst Size Corrects an Otherwise Defective Memory Response by CD8+ Recent Thymic Emigrants J Immunol 196 6: 2450-5