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Rasagiline can be used as either a monotherapy in the early stages of the disease or as an adjunct therapy in the later stages, whereas selegiline is commonly used as an adjunct therapy to levodopa in the later stages of the condition

Nonrodent species should be chosen that are most pharmacologically (e.g., target sequence homology and relative binding affinity) and, for small molecules, metabolically relevant to humans

Cartault F, Munier P, Jacquemont ML, Vellayoudom J, Doray B, Payet C, et al

Pharmacological management, on the other hand, not only centers on the use of neural-modulating agents, but also with agents to remodel the epigenetic chromatin landscape

Youre reacting to what you imagine is the truth rather than the facts, and if nerds have any super power its the ability to play out every possible worst-case scenario imaginable