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Primary Functions Master Antioxidant: It neutralizes free radicals, protecting cells from damage caused by oxidative stress, which is linked to aging and various chronic diseases Detoxification Support: It is heavily concentrated in the liver, where it binds to toxins, heavy metals, pollutants, and drugs, facilitating their excretion from the body

showed that Se boosted GPX1 expression by inhibiting DNMT2-mediated DNA methylation of the GPX1 promoter from lessening ROS production in advanced glycation end-product (AGE)-induced heart failure [114]

45 In showing significant associations between latitude as a surrogate measure of UVR and the frequency of four gene polymorphisms that influence folate cofactor partitioning in folate metabolism, the present findings may provide new insight into folate-related diseases

Glutathione is found in its highest concentrations in the liver because it is essential for both Phase I and Phase II detoxification

Duong, T., Pommier, E.C