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The mTOR directly phosphorylates 4E-BP1 and p70S6K which then phosphorylate S6 to initiate protein translation step

Front Immunol 16:1529756

Common Acne Types: Comedonal acne : Whiteheads and blackheads Inflammatory acne : Papules, pustules, and nodules Cystic acne : Deep, painful, and prone to scarring Hormonal acne : Often along the jawline, flares around menstrual cycles Conventional Treatment: Why It Often Fails Dermatology often treats acne with: Topicals : Benzoyl peroxide, salicylic acid, retinoids Antibiotics : Doxycycline, minocycline Hormonal agents : Birth control, spironolactone Isotretinoin (Accutane) : For severe cystic acne These can be helpful but often come with downsides: Temporary relief Rebound breakouts Side effects : Gut issues, liver stress, mood swings No investigation of root cause Functional medicine asks a different question: Why is your body producing acne in the first place

MeaB binding affinity for its substrate MCM is also affected by nucleotides [225]

S., Laz, N