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Heightened inflammation: Dysregulated NF-kB pathways promote pro-inflammatory cytokines

A knockdown study and a small-molecule mouse study are exactly the steps that should precede a human trial, and they are the reason a compound gets taken seriously enough to be studied further

Functional recovery measured by an activity of daily living score may take as long as 12 months, although single cognitive tests may already show some improvement within 3 months [82]

Some observational research has also suggested a slight increase in lung cancer risk linked to long-term, high-dose B6 and B12 supplementation, particularly among men and smokers, although this kind of study cannot prove that the supplements caused the cancers