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AST-IV protected microglia from lipopolysaccharide-evoked death and down-regulated the release of pro-inflammatory mediators, including interleukin IL-1 , IL-6, tumor necrosis factor (TNF- ), and nitric oxide, as well as, expression of Toll-like receptors 4 (TLR4), MyD88, and NF-B [137]

DNA methylation thus silences transposable elements while activating stress-responsive loci like CBF3 and SOS1 , as validated by WGBS across tolerant genotypes (Gupta and Garg, 2023)

GPXs are members of a multi-enzyme family that catalyze the reduction of H 2 O 2 , organic hydroperoxides and/or lipid hydroperoxides to generate their corresponding lipid alcohols and water at the expense of oxidation of two molecules of GSH [114]

Marden et al., 2007

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