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Addressing safety liabilities of TfR bispecific antibodies that cross the blood-brain barrier

Some minor short-term effects after receiving an IV drip include fatigue, a dry mouth, a headache, or nausea

To specifically knock out ZIP10 in antigen-presenting cells (APC), the ZIP10 gene was conditionally ablated by being put under the control of the invariant chain promotor

Hypoxic preconditioning results in increased motility and improved therapeutic potential of human mesenchymal stem cells

In HFD-fed mice, GSH depletion did not significantly decrease pIR T1150, but it significantly decreased levels of pIRS1 at S1097 and pJNK (Figure 2, O and P), indicating that attenuation of these 2 inhibitory nodes may contribute to the improved insulin sensitivity