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Disturbed levels are found in inborn errors of methionine metabolism as well as in other pathological states such as vitamin B12 or folate deficiency and renal disease

The Genetic Switch: Understanding Nrf2 Activation If glutathione is conceptualized as the primary fuel of the cellular antioxidant system, a crucial question concerns the regulatory engine that governs its synthesis and utilization

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Science 372 , eabf1230 (2021)

Elevated MRP1 protein and/or mRNA levels have been confirmed in many hematologic and solid tumors, and in some instances, are predictors of poor response to chemotherapy (4, 811)