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Description
Specifically, cuproptosis-induced mitochondrial proteotoxic stress promotes the release of mitochondrial DNA (mtDNA), which acts as an intracellular DAMP, 320 activating the tumor-immune-related mtDNA-cGAS-STING signaling pathway and leading to the secretion IFN- and CXCL10
The way the body stores B12 in the liver
This accumulation recruits the E3 ubiquitin ligase Parkin, initiating mitophagy, which removes damaged mitochondria and helps maintain mitochondrial health within cells
10.1016/j.jtemb.2022.127098 126 ZhangM.ZhangX
& Moini, A
