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this, in turn, leads to accentuated elevations in blood concentrations of tHcy and MMA, and exacerbation of neurological sequelae due to vitamin B-12 deficiency in the brain and peripheral nervous system To test these and other predictions, in addition to human studies, it will be important to develop better animal models with closer similarity to the physiologic and clinical features of vitamin B-12 deficiency than rodent models currently provide

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Vitamin B12 is found almost exclusively in animal-derived foods, making dietary intake an important consideration though one with significant limitations following gastric sleeve surgery

Br Med J1963;2:225-7
