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The effects of thiamin and its phosphate esters on dopamine release in the rat striatum

K., Mitri Z., Geryess E., Noutsi P

783 Moreover, intracellularly accumulated F-1,6-BP can bind with HMGB1, decreasing the affinity of HMGB1 for DNA and DNA adducts and sensitizing cancer cells to DNA replication stress and damage induced by chemotherapeutic agents, thereby promoting cancer cell apoptosis

We also detected a significant drop in total GSH in ADH5 cells, which might indicate that the active efflux of HSMGSH could contribute to a drop in the net cellular GSH thus also affecting cellular redox homeostasis (Fig