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Availability of data and materials The RNA-sequencing data has been uploaded to NCBI's Gene Expression Omnibus (GEO) and can be accessed by public ( All data generated or analyzed in this study are included in this article

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In addition, glutamine supplementation studies cannot be judged on trials where only the very sickest patients (i.e., with two or more organ failures) were eligible for this nutritional intervention, and in these situations, supraphysiologic doses are not an appropriate nutritional solution

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