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Characterization of novel SARM1 inhibitors for the treatment of chemotherapy-induced peripheral neuropathy

Together, our observations that a small molecule NNMT inhibitor can increase NAD + and SAM concentrations in differentiated adipocytes and reduce adiposity in DIO mice, suggest that treatment with an NNMT inhibitor effectively reverses obesity via modulation of the NAD + salvage and SAM-mediated (e.g., polyamine flux) pathways to regulate energy expenditure in the adipose tissue

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Hepatic metabolic dysfunction contributes to fatty liver disease, cirrhosis, and other conditions

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