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Despite a series of positive findings on the beneficial therapeutic target for various cardiovascular diseases derived from the evidence from clinical trials, there is still an urgent need for more meaningful, well-designed, randomized controlled trials to better define cardiovascular pharmacotherapy, the safe window of L-carnitine, and the longer-term side effects, including potential atherosclerotic effects

Further mechanism studies confirmed that Lico-A effectively inhibits P

Short term methionine restriction increases hepatic global DNA methylation in adult but not young male C57bl/6j mice

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10.1016/j.cell.2012.02.015 [DOI] [PMC free article] [PubMed] [Google Scholar] 299.Zhao, X