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However, the effects of these drugs are not directly related to their well-known mechanism of action but rather to a secondary mechanism that involves the reduction of ET-1, C-reactive protein (CRP), and the production of monocyte chemoattractant protein-1 (MCP-1)

(American Chemical Society)Thioredoxin reductase (TrxR) is a selenoenzyme that could regulate intracellular oxidative balance and is overexpressed in many human tumor cells

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In humans, the most important are cholic acid and chenodeoxycholic acid, which make up 80 percent of all bile acids