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Figure 6 summarizes the mechanisms by which magnesium deficiency and high Hcy cause DNA damage and accelerated aging

USA 121 , e2314128121 (2024)

[4] [6] The direct delivery of ascorbic acid into the bloodstream allows for supraphysiological concentrations, which could have distinct biological effects, such as pro-oxidant activity in the presence of transition metals or selective cytotoxicity against certain malignant cells, although these applications remain under investigation and are not universally accepted as standard of care

Recently developed procedures such as immunofluorescence and air liquid-interface cell cultures may also be helpful to differentiate PCD from secondary dyskinesia.11 However, these methods require high levels of expertise, and their cost and availability vary among diagnostic centers, even within a country, requiring adapted algorithms.12 An internationally harmonized, adapted and standardized diagnostic algorithm is needed to prevent PCD underdiagnosis

2016;77(4):e457e466
