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Due to lipid peroxidation, polyunsaturated fatty acids inhibiting the spermatozoa membrane are particularly sensitive to the penetration of free radicals

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In cancer patients, intestinal malabsorption (i.e., surgical procedures involving the stomach and duodenum, short bowel syndrome, liver failure), diarrhea and intestinal fistulas, and total parenteral nutrition are all conditions associated with a higher risk of deficiency

Therefore, to investigate the mechanistic link between fumarate accumulation, succination of GSH, and oxidative stress, respiration-competent Fh1 fl/fl cells were incubated with a cell-permeable derivative of fumarate, dimethylfumarate (DMF)

Pasello et al reported that this agent effectively reversed cisplatin resistance in osteosarcoma, alluding toward potentially improved clinical outcomes when using a combination of NBDHEX and cisplatin