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Additionally, in a rat model of adjuvant-induced arthritis, valine and leucine showed lower concentrations in plasma that might result from its consumption as an alternative substrate donor of the TCA cycle, to support the heightened energy demand 56,57

In this review, we describe our current understanding of the multifaceted role of ALA in several inflammatory diseases (acute pancreatitis, arthritis, osteoarthritis, asthma, and sepsis), cardiovascular disorders (CVDs), and neurological conditions

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For example, patches using GHK-Cu peptide have shown promising results in stimulating cellular responses

Otmakhova and Lisman, 1996