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These modifications encompass the stimulation of lymphangiogenesis, an increase in lymph flow (169), structural remodeling of high endothelial venules (HEVs) (170, 171), enhanced recruitment of myeloid cells, and a reduction in effector lymphocytes (172) ( Figure 4C )

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Addition of a macrolide to a beta-lactam-based empirical antibiotic regimen is associated with lower in-hospital mortality for patients with bacteremic pneumococcal pneumonia