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Treatment of Alzheimer's Disease: Current Management and Experimental Therapeutics

For neuron development (Figure 8C), the top genes that were downregulated in both the 10 and 100 ng/mL TNF- conditions were involved in Wnt signaling pathways (e.g., FZD1, FZD2, FZD4, FGFR2, FGFR3, NDP, LGR6, APOE, WLS, FOLR1, NOTCH1 , and EDNRB ), regulation of neurogenesis (e.g., F DZ4, VIM, SLIT2, LPAR3, VAX1, FGFR3, APOE, WLS, PTPRZ1, TNC, NOTCH1, NR2E1, SEMA3B ), and axon guidance (e.g., LAMA3, COL4A6, SLIT2, VAX1, BMPR1B, NDP, OTX2, LGR6, NKX2-1, TNC, NOTCH1, SMEA3B )

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